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No unique dose adjustment advisable when tofacitinib coadministered with strong CYP2C19 inhibitors; minimize tofacitinib dose if coadministered with equally average CYP3A4 and potent CYP2C19 inhibitors .Modafinil may perhaps minimize serum concentrations of other drugs to some clinically major extent, which includes the next:Modafinil has persiste